GENERAL CATALOGUE
cGAS-IN-4
HY-170362 · 5 mg
MedChemExpress · Cat: HY-170362
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medchemexpress.com/cgas-in-4.htmlCatalog No: HY-170362
CAS No: 2987886-49-5
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
cGAS-IN-4 Compound 36 is an orally active inhibitor for cyclic GMP-AMP synthase cGAS with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A HY-P2149 -induced acute liver injury in mouse models. orally active, THP-1, C57Bl/6 mouse, orally active
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