GENERAL CATALOGUE
CH5138303
HY-100555 · 1 mg
MedChemExpress · Cat: HY-100555
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Catalog No: HY-100555
CAS No: 959763-06-5
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90?, with Kd of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines HCT116 and NCI-N87 , with IC50 values of 0.098 and 0.066 ?M, respectively. CH5138303 shows high oral bioavailability in mice F=44.0 % . CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model.
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