Chalcones A-N-5

Description

Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesnAAasAasAat show cytotoxicity at the concentration lower than 100 AAasAasAAmuM with IC50 1 mM, but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by A?1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD.