CHIKV nsP2 protease-IN-2

Description

CHIKV nsP2 protease-IN-2 Compound 2o is a allosteric nonstructural protein 2 helicase nsP2hel inhibitor with IC50s of 0.5 ??M and 0.9 ??M for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus CHIKV , Mayaro virus MAYV , and Venezuelan equine encephalitis virus VEEV EC50 of 120 nM for CHIKV-nLuc . CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research.