CHK1-IN-12

Description

CHK1-IN-12 Compound example 1-5 is an orally active and highly selective checkpoint kinase 1 CHK1 inhibitor with in vitro enzyme IC50?10 nM and cellular IC50?50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis. CHK1-IN-12 is promising for research of cancers.