Chlorthalidone Impurity G

Description

Chlorthalidone Impurity G Chlorthalidone EP Impurity G is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase CA , including isoenzymes CAVB, VII, IX, XII, and XIII Kis=2.8-23 nM and to a lesser extent CAI, CAII, IV, VA, and VI Ki=138-1,347 nM , mediating vasodilatory activity.