CHMFL-ABL/KIT-155

Description

CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155; compound 34 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor IC50s of 46 nM and 75 nM, respectively , and it also presents significant inhibitory activities to BLK IC50=81 nM , CSF1R IC50=227 nM , DDR1 IC50=116 nM , DDR2 IC50=325 nM , LCK IC50=12 nM and PDGFR? IC50=80 nM kinases. CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155 arrests cell cycle progression and induces apoptosis.