GENERAL CATALOGUE
Cholesterol 24-hydroxylase-IN-3
HY-174332 · 5 mg
MedChemExpress · Cat: HY-174332
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Catalog No: HY-174332
CAS No: 1630746-27-8
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
Cholesterol 24-hydroxylase-IN-3 is an orally active, selective, and blood-brain barrier-penetrant CH24H inhibitor IC50 = 23 nM belonging to 1,3-oxazole derivatives. Cholesterol 24-hydroxylase-IN-3 competitively inhibits CH24H enzyme activity by using the 1,3-oxazole nitrogen atom to coordinate the heme iron and the cyclopropyl group occupying the hydrophobic pocket. Cholesterol 24-hydroxylase-IN-3 can be used for research on epilepsy and other neurological diseases.
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