Cilazaprilat

Description

Cilazaprilat is an inhibitor of angiotensin-converting enzyme ACE; IC50=0.7 nM for the rat enzyme and an active metabolite of Cilazapril HY-A0043 . It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 ?M.3 Intra-arterial administration of cilazaprilat 3 ?g/kg per minute increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.