GENERAL CATALOGUE
Cilengitide
HY-16141 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-16141
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Catalog No: HY-16141
CAS No: 188968-51-6
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Cilengitide EMD 121974 is a potent integrins antagonist with IC50s of 0.61 nM ???3 , 8.4 nM ???5 and 14.9 nM ?5?1 , respectively. Cilengitide inhibits the binding of ???3 and ???5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-?/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers.
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