GENERAL CATALOGUE
Cinrebafusp alfa
HY-P99605 · 1 mg
MedChemExpress · Cat: HY-P99605
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Catalog No: HY-P99605
CAS No: 2218515-90-1
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Cinrebafusp alfa PRS 343 is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 Kd=0.3 nM and human monomeric CD137 4-1BB; Kd=5 nM . Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.
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