GENERAL CATALOGUE
Cl-Necrostatin-1
HY-168770 · 1 mg
MedChemExpress · Cat: HY-168770
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medchemexpress.com/cl-necrostatin-1.htmlCatalog No: HY-168770
CAS No: 862377-51-3
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-?-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein FADD; EC50 = 180 nM , a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion MCAO . Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases.
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