Cleaved-Caspase 4/5 p20 Rabbit Polyclonal Antibody

Description

EnkiLife offers the Cleaved-Caspase 4/5 p20 Rabbit Polyclonal Antibody. This antibody reacts with Human species and is suitable for WB,ELISA application. Alternative Names of Immunogen: TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,ELISA 1:5000-1:20000 Background: CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. Research Area: Cell Biology