GENERAL CATALOGUE
CLH304a
HY-129636 · 1 mg
MedChemExpress · Cat: HY-129636
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Catalog No: HY-129636
CAS No: 1611483-29-4
Category: MAPK ERK Pathway
Pack Size: 1 mg
Brand: MedChemExpress
Description
CLH304a compound 14 is a specific and noncompetitive GABAB receptor negative allosteric modulator NAM . CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 ?M. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen HY-B0007 -induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor.
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