GENERAL CATALOGUE
CLPP-2068
HY-173048 · 5 mg
MedChemExpress · Cat: HY-173048
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medchemexpress.com/clpp-2068.html
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Catalog No: HY-173048
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
CLPP-2068 is the orally active activator for human caseinolytic protease P HsClpP with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models.
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