GENERAL CATALOGUE
CMF019
HY-103080 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-103080
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Catalog No: HY-103080
CAS No: 1586787-08-7
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CMF019 is an orally active, potent and small molecule agonist at Apelin receptor APJ with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor APJ is a G protein-coupled receptor GPCR activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension.
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