(-)-CMLD010509

Description

- -CMLD010509 - -SDS-1-021 is an isomer of CMLD010509 SDS-1-021 HY-119271 . CMLD010509 SDS-1-021 is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma MM -including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 SDS-1-021 shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 SDS-1-021 is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism.