

HY-129767 · 50 mg
MedChemExpress · Cat: HY-129767
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medchemexpress.com/cmld012612.html
Description
CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A eIF4A inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase eIF4A and possesses potent anti-neoplastic activity.