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Complement C5-IN-1
GENERAL CATALOGUE

Complement C5-IN-1

HY-128342 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-128342

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Catalog No: HY-128342
CAS No: 2365402-67-9
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Compound C5-IN-1 Compound 7 is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex MAC . Compound C5-IN-1 has an IC50 of 0.77 ?M and 5 nM in 50 % human whole blood and 2 % human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria PNH and atypical hemolytic uremic syndrome aHUS .

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