CoREST Rabbit Monoclonal Antibody

Description

EnkiLife offers the CoREST Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF,ICC application. Alternative Names of Immunogen: COREST; Nr2b2; RCOR; Rcor1; Rxrb;;REST corepressor 1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1000-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:200,ICC 1:50-1:200 Background: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval.