GENERAL CATALOGUE
COTI-2
HY-19896 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-19896
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medchemexpress.com/COTI-2.html
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Catalog No: HY-19896
CAS No: 1039455-84-9
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
COTI-2, an anti-cancer agent with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation.
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