COX-2/5-LOX-IN-4

Description

COX-2/5-LOX-IN-4 Compound 1 is a dual inhibitor that acts on both COX-2 and 5-LOX, with IC50 values of 0.05 ?M for COX-2 and 0.003 ?M for 5-LOX. By inhibiting the arachidonic acid metabolism pathway, COX-2/5-LOX-IN-4 reduces the production of prostaglandins and leukotrienes, alleviating inflammatory responses. In a rat ear edema model, intravenous administration 0.01 and 0.1 mg/kg reduced edema by 41 % and 44 %, respectively, demonstrating significant anti-inflammatory effects. COX-2/5-LOX-IN-4 shows promise for studying the mechanisms of inflammatory diseases.