COX-2-IN-31

Description

COX-2-IN-31 compound 7b is an orally active and dual inhibitor of COX-2 IC50=60 nM and 5-LOX IC50=1.9 ?M . COX-2-IN-31 also inhibits transmembrane hCA IX Ki=48.9 nM and hCA XII Ki=5.8 nM activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity.