GENERAL CATALOGUE
COX-2-IN-55
HY-171992 · 5 mg
MedChemExpress · Cat: HY-171992
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medchemexpress.com/cox-2-in-55.htmlCatalog No: HY-171992
CAS No: 2649115-80-8
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
COX-2-IN-55 compound 1 is an orally active, Celecoxib HY-14398 -based analog with broad-spectrum anticancer activity and weak COX-2 inhibition. COX-2-IN-55 specifically inhibits SERCA2, increases caspase-3 cleavage and DR5 levels, thereby activating GRP78 and inhibiting the development of triple-negative breast cancer TNBC . COX-2-IN-55 can also downregulate the levels of angiogenic markers VEGF-? and IL-8, inhibiting the formation of microvessels.
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