GENERAL CATALOGUE
CP-99994 hydrochloride
HY-12145 · 1 mg
MedChemExpress · Cat: HY-12145
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medchemexpress.com/cp-99994-hydrochloride.htmlCatalog No: HY-12145
CAS No: 145148-39-6
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
CP-99994 hydrochloride is a Tachykinin neurokinin 1 NK-1 receptor antagonist with a Ki of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.
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