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Crelosidenib
GENERAL CATALOGUE

Crelosidenib

HY-131312 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-131312

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Catalog No: HY-131312
CAS No: 2230263-60-0
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Mutant IDH1-IN-6 is a potent, selective and orally active mutant isocitrate dehydrogenase IDH inhibitor with IC50s of 6.27 nM, 3.71 nM, 36.9 nM and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q and IDH2 R172K mutant enzymes, respectively. Mutant IDH1-IN-6 is less active at inhibiting the IDH wild-type enzymes.

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