Cremophor EL-36

Description

Cremophor EL-36 is a nonionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel HY-B0015 . The functions of Cremophor EL-36 include: 1 affecting pharmacokinetics by encapsulating drugs in micelles, changing drug distribution and clearance; 2 activating the complement system and inducing allergic reactions; 3 binding to lipoproteins and interfering with lipid metabolism. Cremophor EL-36 increases drug solubility through micellization, while mediating toxicity through complement activation and lipoprotein interactions.