GENERAL CATALOGUE
cRIPGBM chloride
HY-115630 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-115630
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Catalog No: HY-115630
CAS No: 2361988-77-2
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme GBM cancer stem cells CSCs . cRIPGBM chloride targets to receptor-interacting protein kinase 2 RIPK2 to induce caspase 1-dependent apoptosis. cRIPGBM chloride suppresses the formation of RIPK2/TAK1 prosurvival complex , and increases the formation of RIPK2/caspase 1 proapoptotic complex . cRIPGBM chloride exerts potent anti-tumor activity in vivo in animal models.
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