GENERAL CATALOGUE
Crizotinib-d5
HY-50878S · 1 mg
MedChemExpress · Cat: HY-50878S
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Catalog No: HY-50878S
CAS No: 1395950-84-1
Category: Autophagy
Pack Size: 1 mg
Brand: MedChemExpress
Description
Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib PF-02341066 is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.
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