Crizotinib-d9 hydrochloride

Description

Crizotinib-d9 hydrochloride is deuterated labeled Crizotinib hydrochloride HY-50878A . Crizotinib hydrochloride PF-02341066 hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride PF-02341066 hydrochloride inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 ROS1 inhibitor. Crizotinib hydrochloride PF-02341066 hydrochloride has effective tumor growth inhibition.