GENERAL CATALOGUE
Crizotinib hydrochloride
HY-50878A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-50878A
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medchemexpress.com/Crizotinib-hydrochloride.htmlCatalog No: HY-50878A
CAS No: 1415560-69-8
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Crizotinib hydrochloride PF-02341066 hydrochloride is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride PF-02341066 hydrochloride inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 ROS1 inhibitor. Crizotinib hydrochloride PF-02341066 hydrochloride has effective tumor growth inhibition.
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