CSNK2A2 Mouse Monoclonal Antibody

Description

EnkiLife offers the CSNK2A2 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat,Monkey,Rabbit species and is suitable for WB,IHC,ELISA,FC application. Alternative Names of Immunogen: CK2A2; CSNK2A1; FLJ43934. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt. Research Area: Apoptosis,Wnt signaling pathway