GENERAL CATALOGUE
CSRM617 hydrochloride
HY-122611A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-122611A
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medchemexpress.com/csrm617-hydrochloride.htmlCatalog No: HY-122611A
CAS No: 1353749-74-2
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 OC2, a master regulator of androgen receptor with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model
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