GENERAL CATALOGUE
CTPI-2
HY-123986 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-123986
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Catalog No: HY-123986
CAS No: 68003-38-3
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 ?M. CTPI-2 inhibits glycolysis, PPAR?, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity.
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