GENERAL CATALOGUE
CUR5g
HY-152100 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-152100
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medchemexpress.com/cur5g.htmlCatalog No: HY-152100
CAS No: 1370032-20-4
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin HY-17394 against A549 cells both in vitro and in vivo.