GENERAL CATALOGUE
CXCR2-IN-2
HY-120878 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-120878
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Catalog No: HY-120878
CAS No: 1838123-21-9
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist IC50=5.2 nM/1 nM in ?-arrestin assay/CXCR2 Tango assay, respectively . CXCR2-IN-2 displays 730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-? induced CD11b expression with an IC50 of 0.04 ?M.
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