Cyclin E2 Rabbit Monoclonal Antibody

Description

EnkiLife offers the Cyclin E2 Rabbit Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,IHC,ICC application. Alternative Names of Immunogen: CCNE2; G1/S-specific cyclin-E2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,ICC 1:50-1:200 Background: The human Cyclin E2 gene encodes a 404 amino acid protein that is most closely related to Cyclin E. Cyclin E2 mRNA levels peaks at the G1 / S transition. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 / Cdk2 phosphorylates histone H1 in vitro. G1 cyclin E controls the initiation of DNA synthesis by activating CDK2. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Research Area: PI3K-Akt signaling pathway