GENERAL CATALOGUE
cyclo(CLLFVY)
HY-P10426 · 1 mg
MedChemExpress · Cat: HY-P10426
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medchemexpress.com/cyclo-cllfvy.html
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Catalog No: HY-P10426
CAS No: 1446322-73-1
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress
Description
cyclo CLLFVY is an inhibitor for hypoxia inducible factor-1 HIF-1 , with IC50 of 19 ?M in U2OS and 16 ?M in MCF-7 . cyclo CLLFVY binds to the PAS-B domain of HIF-1?, inhibits HIF-1 dimerization and transcriptional activity. cyclo CLLFVY downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers.
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