Cycloartenyl ferulate

Description

Cycloartenyl ferulate Cycloartenol ferulate; Cycloartenol ferulic acid ester is a derivative of ?-oryzanol HY-B2194 with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFN?R1 binding affinity Kd = 0.5 ?M to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat PQ -triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer NK cells by upregulating the expression of NK cell activation receptors NKG2D, NKp30, NKp44 and the release of cytotoxic molecules and cytokine IFN?. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention.