CYP51/PD-L1-IN-3

Description

CYP51/PD-L1-IN-3 compound L21 is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 IC50: 0.205 ?M and PD-L1 IC50: 0.039 ?M , which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-?Bp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.