GENERAL CATALOGUE
Cytarabine 5 -monophosphate
HY-W344074 · 5 mg
MedChemExpress · Cat: HY-W344074
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Catalog No: HY-W344074
CAS No: 1890354
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
Cytarabine 5?-monophosphate is a metabolite of the nucleoside analog Cytarabine HY-13605 , catalyzed by deoxycytidine kinase. Cytarabine 5?-monophosphate is incorporated into DNA by DNA polymerase ?, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5?-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae S. cerevisiae . Additionally, Cytarabine 5?-monophosphate 3.5-75.1 mg/kg improves survival in leukemia mice L1210 mice . Cytarabine 5?-monophosphate can be used in cancer research.
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