GENERAL CATALOGUE
CZC-25146
HY-15800A · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-15800A
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medchemexpress.com/CZC-25146.htmlCatalog No: HY-15800A
CAS No: 1191911-26-8
Category: Autophagy
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
CZC-25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal ?-1-antitrypsin AAT secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinsons disease and liver diseases.
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