D-Arabinopyranose

Description

D-Arabinopyranose is a rare aldehyde pentose, and its ring-opened form is D-arabinose HY-N0059 . D-arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans IC50 is 7.5 mM . D-arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-arabinose activates the ACSS2-PPAR?/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-arabinose is the ring-opened form of the aldopentose D-?Arabinose HY-N7082 .