GENERAL CATALOGUE
D-CopA3
HY-P10914 · 50 mg
MedChemExpress · Cat: HY-P10914
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Catalog No: HY-P10914
CAS No: 1426227-11-3
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
D-CopA3 is the inhibitor for MDM2 and the activator for p53 signaling pathway. D-CopA3 exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO IC50=15-18 ?M , induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of cell cycle inhibitory protein p21Cip1/Waf1, enhances the mucosal barrier function and reduces penetration of inflammatory mediators. D-CopA3 exhibits anti-inflammtory activity in mouse C. difficile toxin A-induced acute enteritis models and DSS HY-116282 -induced chronic colitis models. D-CopA3 exhibits antitumor efficacy in mouse HCT-116 xenograft models.
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