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D-?-Hydroxyglutaric acid-d5 disodium
GENERAL CATALOGUE

D-?-Hydroxyglutaric acid-d5 disodium

HY-W654003 · 1 mg

MedChemExpress · Cat: HY-W654003

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Catalog No: HY-W654003
Category: Immunology Inflammation
Pack Size: 1 mg
Brand: MedChemExpress

Description

D-?-Hydroxyglutaric acid-d5 disodium Disodium R -2-hydroxyglutarate-d5 is the deuterium labeled D-?-Hydroxyglutaric acid disodium HY-100542 . D-?-Hydroxyglutaric acid disodium Disodium R -2-hydroxyglutarate is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-?-Hydroxyglutaric acid disodium is a weak competitive antagonist of ?-ketoglutarate ?-KG and inhibits multiple ?-KG-dependent dioxygenases with a Ki of 10.87 mM. D-?-Hydroxyglutaric acid disodium increases reactive oxygen species ROS production. D-?-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

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