GENERAL CATALOGUE
D-?-Hydroxyglutaric acid disodium
HY-100542 · 10 mM * 1 mL in Water
MedChemExpress · Cat: HY-100542
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Catalog No: HY-100542
CAS No: 103404-90-6
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in Water
Brand: MedChemExpress
Description
D-?-Hydroxyglutaric acid disodium Disodium R -2-hydroxyglutarate is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-?-Hydroxyglutaric acid disodium is a weak competitive antagonist of ?-ketoglutarate ?-KG and inhibits multiple ?-KG-dependent dioxygenases with a Ki of 10.87 mM. D-?-Hydroxyglutaric acid disodium increases reactive oxygen species ROS production. D-?-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.
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