D-?-Hydroxyglutaric acid disodium (Standard)

Description

D-?-Hydroxyglutaric acid disodium Standard is the analytical standard of D-?-Hydroxyglutaric acid disodium . This product is intended for research and analytical applications. D-?-Hydroxyglutaric acid disodium Disodium R -2-hydroxyglutarate is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-?-Hydroxyglutaric acid disodium is a weak competitive antagonist of ?-ketoglutarate ?-KG and inhibits multiple ?-KG-dependent dioxygenases with a Ki of 10.87 mM. D-?-Hydroxyglutaric acid disodium increases reactive oxygen species ROS production. D-?-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.