GENERAL CATALOGUE
D-I03
HY-124691 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-124691
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medchemexpress.com/d-i03.htmlCatalog No: HY-124691
CAS No: 688342-78-1
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 ?M. D-I03 specifically inhibits RAD52-dependent single-strand annealing SSA and D-loop formation with IC50s of 5 ?M and 8 ?M, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin.
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