GENERAL CATALOGUE
D1/D5 Receptor agonist-1
HY-175001 · 50 mg
MedChemExpress · Cat: HY-175001
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medchemexpress.com/d1-d5-receptor-agonist-1.htmlCatalog No: HY-175001
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
D1/D5 Receptor agonist-1 is a highly brain-penetrant and orally active D1/D5 receptor agonist. D1/D5 Receptor agonist-1 maintains considerable efficacy in the cAMP pathway and in ?-arrestin recruitment, with EC50s of 3.7 nM D1R cAMP , 91 nM D1R ?-arrestin , 129 nM D1R internalization and a Ki of 111 nM D1R binding affinity . D1/D5 Receptor agonist-1 inhibits ?-arrestin signaling in a rat with L-DOPA HY-N0304 induced dyskinesias. D1/D5 Receptor agonist-1 can be used for the study of ParkinsonAAasAasAas disease.
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