GENERAL CATALOGUE
DA-0157
HY-170928 · 50 mg
MedChemExpress · Cat: HY-170928
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medchemexpress.com/da-0157.html
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Catalog No: HY-170928
CAS No: 2756978-82-0
Category: JAK STAT Signaling
Pack Size: 50 mg
Brand: MedChemExpress
Description
DA-0157 is the orally active inhibitor for EGFR and ALK that overcomes drug-resistant mutations of EGFR C797S and ALK in NSCLC cells. DA-0157 inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S IC50 = 6.9 nM , Ba/F3-EGFR WT IC50 = 0.83 ?M , Ba/F3-EML4-ALK-L1196M IC50 = 5.5 nM , and Ba/F3-EML4-ALK IC50 = 7.4 nM . DA-0157 inhibits CYP2D6 with IC50 of 5.26 ?M. DA-0157 exhibits antitumor efficacy in mouse models.
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